Caffeine and fertility

        Caffeine is the most consumed stimulant in the world and coffee is the most important source of caffeine. Research has shown a link between caffeine and fertility, with high coffee consumption being associated with an increased risk of suboptimal sperm motility, delayed conception, infertility and problems with the outcome of assisted reproduction.

          The CYP1A2 gene produces an enzyme called cytochrome P450 1A2 (CYP1A2), which is the main enzyme responsible for breaking down caffeine in the body. Variations in the CYP1A2 gene affect the rate at which caffeine is broken down. Individuals who possess the AA or GA variant of CYP1A2 break down caffeine more slowly. This may influence how caffeine affects reproductive functions and fertility, compared to individuals who have the GG variant of the CYP1A2 gene.

       If you have the AA or GA variant of the CYP1A2 gene, excessive caffeine consumption can cause complications during pregnancy. Limit your caffeine intake to less than 100 mg/day. Caffeine occurs naturally in coffee, tea, cocoa, cola and guarana. It is also manufactured synthetically and added to cola, energy drinks and some medicines.

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