MTHFR and hypertension
There is a relationship between the blood pressure response in those in whom high blood pressure is associated with homozygosity for the common C677T polymorphism of the MTHFR gene. The homozygous TT variant is associated with a decreased enzymatic activity of methylenetetrahydrofolate reductase (MTHFR). This is due to the loss of riboflavin, which, as a coenzyme precursor and electron carrier flavin adenine dinucleotide (FAD) is required as a cofactor for MTHFR. Riboflavin appears to stabilize MTHFR in vivo and a variety of randomized controlled trials have subsequently shown that riboflavin supplementation significantly reduces systolic blood pressure by 5-13 mmHg, specifically in individuals with the MTHFR 677 TT genotype.
MTHFR C677T genotype
Impact of
diet:
Wild type CC
Heterozygous CT moderate
Homozygous TT high
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