You can apply the results of
certain genes in your report to breast cancer prevention. When you know that
you have certain variants in these genes, it helps in more individualized
prevention, as you will understand how your DNA influences your health and what
habits you should adopt to strengthen your body. Here are some polymorphisms
associated with breast cancer:
CYP2R1: Variants in CYP2R1
increase the need for vitamin D. Research has shown that women with the highest
amount of circulating vitamin D were associated with a 45-50% decrease in the
risk of breast cancer when compared to those women with the lowest amount of
vitamin D. BRCA1 expression is also key in
mediating the biological impact of vitamin D3 on breast tumor cells, which
means that you have to support BRCA first before vitamin D can do its job. The
ideal range seems to be between 35 and 50 ng/ml. Vitamin D may also inhibit the
estrogen pathway and reduce the expression of the aromatase gene, a gene
encoding an enzyme that converts androgens to estrogens.
MTHFR, MTHFD1, and DHFR: All
genes should be reviewed to assess folic acid sensitivity and folate
requirements. High circulating levels of synthetic folic acid found in
fortified foods and synthetic supplements have been associated with an
increased risk of breast cancer. Those with the BRCA mutation and high
circulating folic acid had a 3.2-fold increased risk of breast cancer for high
circulating folic acid. It seems hypothetical that having
your first child in your 30s while supplementing with synthetic folic acid
combined with low zinc, selenium, and choline intake would be a recipe for
aggressive breast cancer growth in those genetically susceptible.
BCMO1: Variants reduce the
ability to convert beta-carotene to vitamin A, increasing the need for
animal-based vitamin A. Vitamin A modulates the epigenome and reverts
pre-cancerous breast cells to normal cells, but not full cancer cells, making
it more effective for prevention.
Comments
Post a Comment