Pregnant and MTHFR

    Folate has an important role in modulating DNA epigenetics, as epigenetic control of DNA methylation patterns is fundamental for the regulation of gene expression. It is recommended that women with polymorphism of the MTHFR gene, the use of folate supplements (methylfolate or folinic acid), which must be taken at least 1 month before eventual conception and during pregnancy it must be maintained until the third month, suspending it after completing 12 weeks. It is important to highlight that folate absorption is dependent on an enzyme called metalloenzyme, zinc dependent and deficiency of this mineral can impair folate absorption.