The ApoE gene and the risk of Alzheimer's

      The ApoE gene (together with other genes) has a very strong correlation with the disease of Alzheimer's. When we carry out genetic tests, we discover two copies of the ApoE gene, which we inherit one from another and another from each other. What could be the following possible isoforms: 

APOE type	rs429358	rs7412	Alzheimer's risk
E2/E2	TT	TT	lowest risk x 0.6
E2/E3	TT	TC	lowest risk x 0.6
E3/E3	TT	CC	most common odds ratio
E2/E4	TC	TC	above average risk x 2.6
E3/E4	TC	CC	high risk x 3.2
E4/E4	CC	CC	highest risk x 14.9

This is very important, because there is no pharmaceutical treatment for Alzheimer's disease. Thus, knowing the risk at hand can help prevent it from appearing later in the event.

 How should we prevent Alzheimer's, if we have an ApoE4 allele?

-Adopt a low carb diet with a low glycemic index: if you have insulin resistance;

-Do physical exercise regularly: increase the expression of BDNF, which helps brain cells grow. Taking fish oil (which includes 1000 mg DHA) and curcumin before exercise potentiates or increases BDNF;

-Have balanced sound noises: sound deprivation causes long-term brain degradation (diminution of the volume of the hippocampus, as well as part of the brain impacted by Alzheimer's;

 -If you are a carrier of the MTHFR gene polymorphism, check your homocysteine ​​levels and certify that you supplement folate deficiency with: methylfolate or folinic acid;

-Monitor your Vitamin D levels;

-Prefer magnesium threonate: this form of magnesium is more bioavailable to the brain;

-Consume antioxidants rich in resveratrol and quercetin that protect the brain from oxidative damage;

-Check levels of heavy metals in the body, for neurotoxins;

-Check LDL and ApoB levels;

-Avoid alcohol consumption.

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