Causes of hormonal migraines

1. Hormonal Shifts (Mainly Estrogen)

- Drops in estrogen and/or progesterone shortly before menstruation and low levels during.

- Rising estrogen after menstruation.

- Surge of estrogen at ovulation followed by a sharp drop.

 

2. Histamine Intolerance

- Elevated histamine levels (common around ovulation and PMS time) can promote estrogen release, creating a feedback loop.

- Estrogen can reduce the activity of diamine oxidase (DAO), an enzyme that breaks down histamine and upregulate histamine release, while progesterone can suppress DAO, leading to histamine buildup.

 

3. Gut and Liver Health

- Poor gut health or dysbiosis can increase histamine production and reduce DAO levels; the gut also plays a critical role in estrogen metabolism (elevated beta glucoronidase levels can be an indicator of imbalance).

- Liver congestion or dysfunction can impair hormone metabolism detoxification, leading to estrogen dominant headaches.

 

4. Nutrient Deficiencies

- Magnesium, B vitamins, vitamin C, Iodine, Folate, Iron and Manganese deficiencies can worsen headaches by affecting neurotransmitter function, inflammation, and detoxification pathways. Patterns and trends from labs can help reflect bio-individual needs.

 

5. Prostaglandins and Inflammation

- Elevated prostaglandins during menstruation can trigger inflammation and vasodilation.

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