COMT and psychiatric disorders

     The COMT Val158Met polymorphism, resulting in the substitution of valine (Val) for methionine (Met) at position 158 of the COMT enzyme, is associated with differences in dopamine levels and neurotransmitter function. Individuals with the Val/Val genotype, associated with higher COMT enzyme activity, may be at increased risk for psychiatric disorders.

 

Slow COMT (met/met):

- better performance on attention-related tasks

- improved working memory

- more sensitive to stressful events, higher cortisol (children, adolescents)

- more likely to avoid harm (less novelty seeking)

- increased relative risk of OCD, panic disorder, pain disorders

 

Fast COMT (val/val):

- less cognitive decline in aging

- less sensitive to stressful events

- better at processing aversive emotional stimuli

- greater extroversion and more novelty seeking

- increased relative risk of ADHD, substance abuse

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