DAO gene

     DAO stands for D-amino acid oxidase because the gene encodes the peroxisomal enzyme of the same name. The enzyme is found in almost all organs but mostly in the small intestine, kidneys, colon, prostate, and placenta. The DAO gene and enzyme are necessary to make histamine. Histamine lives inside and outside of cells, and DAO is needed for proper histamine control and balance.

The body gets histamine in a few key ways:

-From foods like fermented vegetables, alcohol, and cheese

-From certain Lactobacillus probiotics

-From the immune system in response to irritants

    The body needs certain amounts of histamine for health. However, too much histamine leads to misery like allergic reactions and even autoimmunity sometimes.

    This gene strongly influences how sensitive you are to the world around you, particularly to toxins and food. DAO can impact your body’s response to histamine, which is found in food, beverages, and the environment. The body needs certain amounts of histamine for health. However, too much histamine leads to adverse reactions and even immune system issues. Conditions related to DAO SNP include:

•Food sensitivities and other reactions (hives, rhinitis, itching, rashes)

•Digestive tract issues

•Small intestinal bacterial overgrowth (SIBO)

•Pregnancy complications

•Breathing problems

•Bowel issues

•Eczema and other skin conditions

•Heartburn, GURD, and acid reflux

•Vertigo