Dopamine

     Dopamine (3,4-dihydroxyphenethylamine) is an important excitatory neurotransmitter that functions as both a hormone and a neurotransmitter and plays several important roles in the brain and body. It is synthesized in the brain and kidneys. Dopamine is a powerful neurotransmitter, sometimes called the “feel good” neurotransmitter. It is not only involved in pleasure, but also in reward (motivation). Dopamine synthesis consists of three steps. First, phenylalanine is converted to another amino acid, tyrosine. Next, tyrosine hydroxylase (TH) catalyzes the conversion of tyrosine to L-Dopa. Finally, L-Dopa is converted to dopamine.

When dopamine is low, you may feel or experience:

-depression

-lack of energy, drive

-low libido

-lack of motivation or satisfaction

-mood swings

-obsessive-compulsive disorder (OCD)

-inability to lose weight

-cravings for caffeine or other stimulants

-lack of focus and concentration

-memory loss or inattention

-addictions of some kind

When dopamine is high, you may feel or experience:

-Symptoms of mania

-excessive suspiciousness

-excessive excitement about challenges and achievements

-constipation

-aggression

-schizophrenia

-hyperactivity

-Tourette syndrome

Drugs that interact with Dopamine

Dopamine Reuptake Inhibitors: Wellbutrin (Bupropion)

Dopamine Receptor Agonists: Mirapex, Sifrol, Requip

D2 Dopamine Receptor Blockers (antipsychotics): Thorazine, Prolixin, Trilafon, Compazine, Mellaril, Stelazine, Vesprin, Nozinan, Depixol, Navane, Iuanxol, Clopixol, Acuphase, Haldol, Orap, Clozaril, Zyprexa, Zydis, Seroquel, Geodon, Solian, Invega, Abilify

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