DRD2 gene

    The DRD2 gene codes for the D2 dopamine receptor. Unlike several other major types of dopamine receptor, DRD2 receptors are inhibitory. This means that having more of them results in lower overall dopamine levels in the brain, and vice-versa.

    Because dopamine is highly involved in reward processing, motivation, and many other processes critical for proper cognitive function, SNPs in the DRD2 gene can have a significant impact on overall cognitive ability.

    In this light, it is not too surprising that SNPs in this gene have been associated with cognitive flexibility, learning and memory, working memory , problem-solving ability, creativity, and overall intelligence (IQ).

    DRD2 SNP rs1800497 (‘GG’; homozygous major) is associated with roughly normal levels of cognitive ability compared to carriers of the beneficial ‘A’ allele, who show increased cognitive ability.

    Getting plenty of regular exercise is one of the best ways to boost your dopamine levels. Exercise increases the production (synthesis) and release of dopamine, as well as reduces the rate at which it is broken down (metabolized).

    Many different natural supplements can increase your dopamine levels. One particularly good choice i s tyrosine. This amino acid is a metabolic precursor of dopamine; that is, your brain uses tyrosine to make dopamine.

    Supplementing with tyrosine therefore gives your brain the critical building blocks it needs to create dopamine and directly increases overall dopamine levels. These increases, in turn, can enhance several important cognitive functions, such as cognitive flexibility.

    Two other handy, all-natural supplements for your genotype are Bacopa monnieri and Mucuna pruriens. Bacopa enhances cognitive function by boosting dopamine levels, and is widely used as a cognitive enhancer (or “nootropic”).

Mucuna contains L-DOPA (levodopa) which, like tyrosine, is an important metabolic precursor of dopamine. L-DOPA can be especially beneficial because it readily crosses the blood-brain barrier (BBB), allowing it to easily and effectively reach the brain. It has also been found to enhance learning and memory