DRUGS INTERACTIONS

-Metronidazole + Warfarin

Metronidazole inhibits the metabolism of warfarin by blocking CYP2C9 may lead to fatal bleeding.

 

-Furosemide + Gentamycin

Leads to hearing loss.

 

-Sildenafil + Sublingual Nitroglycerin

Both causes Vasodilation, severe hypotension and maybe death.

 

-Non dihydropyridine (Verapamil, Diltiazem) + Beta Blockers

Both cause severe bradycardia and heart block.

 

-Tetracyclines + Penicillins

Tetracyclines are bacteriostatic, inhibits growth of bacteria while penicillin work only on actively dividing organisms.

 

-Antacids or Anti-Ulcer + Iron In pt. with IDA

Iron needs acidic to be absorbed.

 

-Omeprazole + Clopidogral

Omeprazole decreases effect of clopidogral by affecting hepatic enzyme CYP2CI9 metabolism.

 

-Azithromycin + Antihistamines

Severe chest pain and prolong QT intervals.

 

-Ondansetron + Tramadol

Ondansetron decreases analgesic effect of tramadol.

 

-Warfarin + NSAIDs

Increase the risk of GIT bleeding.

 

-K sparing diuretics + ACEI (Captopril)

Leads to hyperkalemia.

 

-Statin + Gemfibrozil

Increase risk of myopathy.

 

-Ciprofloxacin, Cimitidine, Fluvoxamine, Clarithromycin, Erythromycin + Theophylline

These drugs are CYP450 inhibitors leads to inc. in Theophylline level in blood leading to death.

 

Ondansetron is the most safest and most effective anti-emetic in children.

 

Fluconazole (Antifungal) must be taken with fatty meal to increase absorption.

 

All breastfeeding baby's should receive Vit.D supplements til the age of 1 year.