Genes can contribute to a leaky gut

GENE	CONDITION ASSOCIATED	ROLE	CONNECTION WITH LEAKY GUT
DAO	Histamine intolerance	Breaks down histamine in the gut.	Excess histamine increases zonulin levels, which results in leaky gut.
MTHFR	Various, including histamine intolerance and impaired methylation.	Converts dietary folate to methylfolate, contributing to methylation, which is linked to overall health and gut functionality.	High homocysteine ​​contributes to general inflammation and metabolic issues that cause damage to the gut lining.
HNMT	Histamine intolerance	Breaks down histamine throughout the body.	Can lead to damagingly high levels of histamine throughout the body.
HLA-DBQ	Celiac disease	Associated with an immune response to gluten.	Celiac disease can damage the lining of the intestines.
ALDH2 and ALDH1B1	Causes the activity of the DAO enzyme to slow down, resulting in histamine intolerance. Also results in accumulated aldehyde levels.	Alcohol metabolism	Alcohol is high in histamine and promotes candida overgrowth. When alcohol is broken down, a toxic byproduct called acetaldehyde is formed. Acetaldehyde can damage the tight junctions (gates) between intestinal cells and make them more permeable.
PEMT	Fatty liver, gallbladder dysfunction, estrogen dominance and metabolic dysregulation.	Synthesizes phosphatidylcholine (PC) necessary for cell membrane integrity, bile flow and metabolic health.	Affects bile flow, leading to increased susceptibility to infections. intestinal tract infections, SIBO, candida overgrowth, and damage to the intestinal lining. It affects liver function, the primary organ responsible for methylation processes. Poor estrogen metabolism can increase histamine levels, which damage the intestinal wall.