Histamine Intolerance and Reproductive System

 Oestrogen excess

 • Histamine promotes oestradiol (E2) synthesis. E2 stimulates mast cell histamine release.

• Can co-exist with HIT.

Dysmenorrhoea/premenstrual cramps

• Histamine promotes E2 synthesis stimulating mucosal prostaglandins and uterine contractions.

• Associated with increased sensitivity to histamine.

Menstrual migraines/headaches

• Histamine stimulates nitric oxide (NO) secretion in brain arteries.

Ovarian endometriomas

• Increased MC concentration leads to degranulation induced by local E2.

Endometriosis

• Elevated blood and endometrial lesion histamine levels activates local nerves increasing pelvic pain intensity.

Pelvic adhesions

• Elevated follicular fluid histamine produces local inflammation and impaired ovulation.

Implantation failure

• Excessive histamine promotes Th1/Th2 imbalance.