Homocysteine and glutathione metabolism

   High or low homocysteine ​​levels are often linked to impaired glutathione metabolism, which affects liver detoxification, which is essential for keeping our liver healthy.

   Many people turn to supplementation with vitamins B6, B9 and B12, as they play crucial roles in the remethylation of homocysteine. Vitamin B9 donates a methyl radical to B12, which then helps transform homocysteine ​​into methionine. B6, on the other hand, works to convert homocysteine ​​into cysteine ​​and, subsequently, into glutathione. But did you know that this supplementation doesn’t always bring the expected results? It is essential to assess the patient’s glutathione status!

  Inflammation and chronic stress can inhibit the enzyme Methionine Synthase, leading to the accumulation of homocysteine. On the other hand, high demand for glutathione can result in low homocysteine ​​levels, indicating a lack of essential nutrients.

   Both hyper and hypohomocysteinemia can be harmful, and METABOLOMICS is the key to understanding what is really happening in the body. With this approach, we can evaluate functional markers of B vitamins and other essential metabolites, allowing a more complete view of the patient's health. It is not just about measuring homocysteine, but understanding the entire metabolic map for effective and personalized treatment.