Hormonal Regulation of Neurotransmitter Activity

Estradiol and Serotonin

Estradiol synergizes serotonin signaling – it stimulates biosynthesis, enhances receptor activation, blocks reuptake, and inhibits degradation.

Imbalances can cause:

-Hot flashes

-Night sweats

-Mood swings

-Irritability

-Anxiety

-Depression

  

Progesterone and GABA

Via allopregnanolone, progesterone modulates GABA production and GABA A receptor signaling.

Imbalances can cause:

-PMS/PMDD

-Anxiety

-Sleep problems

-Depression

-Mood swings

 

S-DHEA

Stimulates adequate production of glutamate, dopamine, norepinephrine and adrenaline. Imbalances can cause:

-Decreased stamina

-Fatigue

-Low libido

-Feeling “tired and wired”

-Depression

-PTSD

 

Testosterone and Dopamine

Testosterone enhances dopamine signaling – it stimulates biosynthesis and blocks degradation.

Imbalances can cause:

-Feelings of exhaustion

-Low libido

-Irritability

-Addictive behaviors

-Apathy

-Depression