Reducing inflammation

    When working with chronic inflammation in clinical practice, the focus has typically been on reducing inflammation, however, re-examining chronic inflammatory diseases through the lens of failed or dysregulated resolution is crucial to assist with resolution of inflammation.

    SPMs are molecules that are derived endogenously from arachidonic acid, docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and are produced to counterbalance inflammatory cues. Unlike conventional anti-inflammatories, SPMs not only work by blocking the inflammatory process, but also by reprogramming immune cells and enhancing leukocyte efferocytosis, thus assisting with terminating and resolving the inflammatory process.

    The turning point in the transition from na inflammatory to a non-inflammatory state is a switch in the synthesis of lipid mediators from pro-inflammatory lipid mediators to the synthesis of specialised pro-resolving mediators (SPM’s) during the acute inflammatory phase.

Essential fatty acids

-Must be acquired through diet

 

Conditionally essential fatty acids support:

• Cell membrane integrity

• Brain and eye health

• Healthy triglycerides levels

• Heart health

 

Unique role in supporting the resolution of the imune response and inflammation - necessary for healthy aging and active living

• Neutrophil activity is curtailed

• Macrophages remove dead neutrophils, bacteria and debris

• Tissue is remodeled

• Return to homeostasis (cells' previous normal conditions)