SAM/SAH ratio

Benefits of optimizing the SAM/SAH ratio:

- Improved neurotransmitter metabolism: Normal methionine activity is important for balanced serotonin reuptake. Correction improves conditions related to abnormal neurotransmitter activity, including depression, OCD, autism, schizophrenia, and bipolar disorder.

- Reduced neurotoxicity: Individuals with OCD often suffer from NMDAR toxicity or excessive glutamate activity. Improving the SAM:SAH ratio can increase methylation, potentially reducing NMDAR hyperactivity and balancing glutamate levels.

- Reduced risk of complex health problems: Proper methylation affects DNA synthesis and repair, immune regulation, and detoxification processes. An optimal SAM:SAH ratio helps prevent a wide range of conditions, including neurodegenerative diseases, autism, cardiovascular disease, and certain cancers.

- Support for Detoxification and Antioxidant Defense: The transsulfuration pathway, which diverts homocysteine ​​to cysteine ​​production, is critical for glutathione synthesis. Glutathione is crucial for combating oxidative stress and aiding in the detoxification of harmful substances.

LOW SAM/SAH:

Poor methylation status

Consider 5-MTHF, vitamin B12, or SAM-e

Consider Mg, Zn support

Consider betaine supplementation

HIGH SAM/SAH:

Consequence of high BMI

Consequence of high protein intake

Potential overmethylation (evaluate supplementation)