Types of neurotransmitters
1. Amino Acids
Examples: Glutamate, GABA (Gamma-Aminobutyric Acid), Glycine
Functions:
- Glutamate: The primary excitatory
neurotransmitter in the brain, essential for learning and memory.
- GABA: The main inhibitory
neurotransmitter, responsible for reducing neuronal excitability and promoting
relaxation.
- Glycine: Acts as an inhibitory
neurotransmitter, particularly in the spinal cord.
2. Monoamines
Examples: Dopamine, Serotonin, Norepinephrine, Epinephrine, Histamine
Functions:
- Dopamine: Regulates reward,
motivation, and motor control.
- Serotonin: Involved in mood
regulation, appetite, and sleep.
- Norepinephrine: Plays a role in
alertness, attention, and the fight-or-flight response.
- Epinephrine: Also known as adrenaline,
it prepares the body for stress-related responses.
- Histamine: Regulates immune responses,
gastric acid secretion, and wakefulness.
3. Peptides
Examples: Substance P, Endorphins, Oxytocin
Functions:
- Substance P: Involved in pain
perception.
- Endorphins: Natural painkillers that
also create a sense of euphoria.
- Oxytocin: Plays a role in social
bonding, childbirth, and lactation.
4. Purines
Examples: ATP (Adenosine Triphosphate), Adenosine
Functions:
- ATP acts as a signaling molecule in
pain and other physiological processes.
- Adenosine promotes sleep and
suppresses arousal.
5. Others
Examples: Acetylcholine, Nitric Oxide
Functions:
- Acetylcholine: Vital for muscle
contraction, memory, and attention.
- Nitric Oxide: Acts as a gaseous
neurotransmitter, involved in vasodilation and neural plasticity.
Functions of Neurotransmitters
- Mood and emotion (e.g., serotonin, dopamine)
- Cognition and memory (e.g., acetylcholine, glutamate)
- Sleep and wake cycles (e.g., serotonin, histamine)
-Stress and arousal (e.g., norepinephrine, epinephrine)
-Pain perception (e.g., substance P, endorphins)
-Motor control (e.g., dopamine,
acetylcholine)
Drug Interaction with Neurotransmitters
-Antidepressants: SSRIs (Selective
Serotonin Reuptake Inhibitors) increase serotonin levels.
-Anxiolytics: Benzodiazepines enhance GABA's inhibitory effect.
-Stimulants: Amphetamines increase dopamine and norepinephrine release.
-Painkillers: Opioids mimic endorphins to reduce pain.
-Hallucinogens: Alter serotonin receptor activity.
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